Both Wegovy (semaglutide) and Metformin have been discussed in the context of weight management. However, only one of these medications, Wegovy, is prescribed specifically for weight loss. Metformin, on the other hand, is primarily a diabetes drug that has been observed to have moderate effects on weight reduction in certain patients. Understanding the key differences between these medications is essential for those considering pharmaceutical options for weight management.

What Is Wegovy?

Wegovy is a prescription medication specifically approved for chronic weight management and as a treatment for adults with obesity. It contains semaglutide, a GLP-1 receptor agonist that helps regulate appetite and food intake. Wegovy is administered as a once-weekly injection and is approved for adults and adolescents who meet specific BMI criteria for weight loss. It is designed to help patients lose a significant percentage of their body weight when combined with a reduced-calorie diet and increased physical activity.

What Is Metformin?

Metformin is an oral medication primarily prescribed to manage blood sugar levels in individuals with type 2 diabetes. It works by improving insulin sensitivity and reducing glucose production in the liver. While it is not usually prescribed for weight loss, some patients experience moderate weight reduction, particularly those with insulin resistance or conditions like polycystic ovary syndrome (PCOS). Metformin is widely used due to its affordability and effectiveness in diabetes management.

Metformin Vs. Wegovy: Mechanisms of Action

• Wegovy Injections: The active ingredient in Wegovy, semaglutide, is a GLP-1 receptor agonist. It works by mimicking the glucagon-like peptide-1 (GLP-1) hormone, which plays a role in insulin secretion, digestion, and appetite regulation. By enhancing the effects of GLP-1, Wegovy reduces hunger, increases feelings of fullness, and slows down stomach emptying, leading to significant weight loss.
• Metformin: Metformin is an oral medication primarily used to treat type 2 diabetes. It works by improving insulin sensitivity, decreasing glucose production in the liver, and reducing sugar absorption in the intestines. While Metformin is not specifically a weight-loss drug, some individuals experience modest weight loss as a secondary effect, primarily due to its role in improving insulin resistance and possibly affecting appetite regulation.

Prescribed Populations

• Wegovy: Indicated for individuals with a body mass index (BMI) of 30 or higher or those with a BMI of 27 or higher with at least one weight-related comorbidity such as diabetes, hypertension, or high cholesterol.
• Metformin: Primarily prescribed for individuals with type 2 diabetes to help control blood sugar levels. It is occasionally prescribed off-label for weight management, particularly for individuals with insulin resistance or polycystic ovary syndrome (PCOS), but it is not approved for weight loss.

Wegovy Vs. Metformin: Effectiveness for Weight Loss

• Wegovy: Clinical trials have demonstrated that patients taking Wegovy can lose up to 15% or more of their total body weight. This is due to its direct impact on hunger regulation and food intake reduction. Maximum results are achieved when Wegovy is combined with a healthy diet and increased physical activity.
• Metformin: Metformin is NOT prescribed to treat obesity or any other health condition other than type 2 diabetes. Weight loss with Metformin is typically much more modest, with studies showing an average weight reduction of 2-5% of total body weight. Unlike Wegovy, the weight loss associated with Metformin is often indirect and dependent on other factors such as diet and insulin sensitivity.

Comparative Results

• Wegovy: Provides substantial weight loss results, making it a more effective option for people without diabetes primarily seeking weight reduction. There are also other benefits of Wegovy as compared to Metformin such as a reduced risk of heart disease in people with obesity.
• Metformin: May help individuals with insulin resistance lose a small amount of weight, but it is not nearly as effective as Wegovy. It is designed not for weight reduction but to lower blood glucose levels and is approved only as a treatment for type 2 diabetes.

Approved Uses and Legality of Use

• Wegovy: Specifically approved for weight management in both adults and adolescents (ages 12 and older) who meet specific BMI criteria.
• Metformin: Indicated to treat type 2 diabetes. While some physicians prescribe it off-label for weight loss or conditions like PCOS, this is not its primary intended use.

Administration and Usage

• Wegovy: Administered as a once-weekly subcutaneous injection.
• Metformin: Taken orally, typically in tablet or extended-release form, and usually prescribed to be taken once or twice daily with meals.

Dosage

• Wegovy: A titration schedule is followed, gradually increasing from 0.25 mg weekly to a target dose of 2.4 mg weekly over several months.
• Metformin: The dosage varies but commonly starts at 500 mg once or twice daily and may be increased up to 2,000 mg per day based on a doctor’s guidance.

Cost

• Wegovy: The cost of Wegovy is typically around $1,600 per month without insurance.
• Metformin: A significantly more affordable medication. The average cost is often less than $50 per month and is generally covered by most insurance plans.

Insurance Coverage

• Wegovy: Insurance coverage varies, as many insurers are hesitant to cover medications specifically prescribed for weight loss, but this is improving.
• Metformin: Almost always covered by insurance for its primary use in diabetes management.

Wegovy Vs. Metformin Side Effects

Both medications come with potential side effects, though their nature differs.

• Wegovy: The most common side effects of Wegovy include:
  • Nausea
  • Vomiting
  • Indigestion
  • Diarrhea or constipation
  • Abdominal pain
  • Rare, but serious risks include pancreatitis and gallbladder disease.

While this may seem like a long list of adverse effects, it is important to point out that for most weight loss patients, the benefits of Wegovy far outweigh its potential risks.

• Metformin: The most common side effects of Metformin include:
  • Gastrointestinal side effects (nausea, diarrhea, stomach cramps)
  • Loss of appetite
  • Metallic taste in the mouth
  • Rarely, lactic acidosis (a serious but uncommon side effect)

Regardless of which drug you are prescribed, please tell your healthcare provider about any other medications you are taking, particularly diabetes medications. Also, be sure to tell your doctor about any history of medical conditions you are aware of.

Allergic reactions can occur with either medication. Tell your prescriber about any known allergies to medications.

Conclusion

When comparing Wegovy and Metformin for weight loss, it is evident that Wegovy is the more effective weight loss medication, as it is specifically designed and approved for weight reduction. While Metformin may contribute to modest weight loss in individuals with insulin resistance or diabetes, it is not primarily a weight-loss drug. For those seeking significant weight loss results, Wegovy is the preferred choice.

Though its cost and insurance coverage may be limiting factors for some, we will work with you to develop a treatment plan that fits your needs as well as your budget. If you are considering medication for weight loss, contact us today and speak to our healthcare providers to determine the best option for your needs.

Now that you know that Wegovy is the better option for weight loss when compared to Metformin, why not Contact Us today and see how we can get you started on your Wegovy weight loss journey?

Wegovy and Rybelsus are both brand-name medications developed by Novo Nordisk. They share the same active ingredient, semaglutide, which belongs to a class of drugs called GLP-1 receptor agonists (GLP-1 RAs). These medications help regulate blood sugar, slow digestion, and reduce appetite. As a result, many patients experience weight loss while on semaglutide.

However, there is one major distinction when it comes to their approved indications for use. Only one of these medications is actually a “weight loss drug.” Wegovy was the first version of semaglutide approved for weight loss in adults who are obese or overweight with at least one weight-related medical condition.

On the other hand, Rybelsus is used to improve blood sugar control in adults with type 2 diabetes. While it often leads to weight loss, its on-label use is not specifically for chronic weight management.

Another significant difference is administration. Wegovy is given as a once-weekly injection. This is how all versions of semaglutide are given when prescribed for weight loss. Rybelsus is a pill. Clinical trials have not yet proven the effectiveness of semaglutide when it is taken in oral form.

Let’s delve deeper into each medication and then examine their key differences.

What is Wegovy?

Wegovy is an injectable form of semaglutide specifically formulated and approved for long-term weight management. In fact, in 2021, it was the very first GLP-1 RA to be tested and officially approved for long-term weight management in people with obesity. It’s indicated for:

• Adults with a body mass index (BMI) of 30 kg/m² or higher (obesity) or
• Adults with a BMI of 27 kg/m² or higher (overweight) also have a weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol.

Wegovy mimics a hormone called GLP-1, which helps regulate appetite and food intake. Patients often report feeling full sooner and experiencing reduced cravings, leading to a lower calorie intake and weight reduction over time. Wegovy is usually taken once a week as a subcutaneous injection. The dose is gradually increased over several months to help minimize common side effects, particularly gastrointestinal (GI) issues.

 

What is Rybelsus?

Rybelsus is a prescription medication that is used to treat patients with type 2 diabetes, and while it shares the same active ingredient as Wegovy – semaglutide – it is NOT a weight loss drug. Rybelsus is an oral version of semaglutide made by the same drug company as Wegovy. It is not intended for weight management or prescribed as an obesity treatment. By helping to regulate how your body releases insulin, Rybelsus can lead to better blood glucose control. A secondary effect of this regulation could be weight loss, which can be beneficial for many people living with type 2 diabetes.

Although weight loss is not the primary goal of Rybelsus, some healthcare providers prescribe it for weight management in patients who might not qualify for Wegovy or for those who prefer an oral medication over an injectable one. However, this is not the intended purpose of this drug, nor has it ever been specifically tested as a weight loss drug.

What Are the Seven Main Differences Between Wegovy and Rybelsus?

While Wegovy and Rybelsus share the same active ingredient – semaglutide – there are significant differences between the two drugs. The seven main differences between Rybelsus and Wegovy are as follows:

1. Wegovy Vs Rybelsus: What Are They Prescribed For?

Only one of these drugs – Wegovy – is specifically prescribed as an obesity treatment in adolescents and adults.

Wegovy

• Indication: Chronic weight management (FDA-approved).
• Ideal Candidates: Adults with obesity (BMI ≥ 30) or overweight (BMI ≥ 27) plus a weight-related condition (e.g., hypertension, type 2 diabetes, or dyslipidemia). Wegovy also has been found to lower the risk of cardiovascular disease, and this indication has been authorized for its label. Rybelsus does not have the same indication.

Rybelsus

• Indication: FDA-approved to treat Type 2 diabetes management. As a diabetes treatment, GLP-1s stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner
• Off-label Use: Some clinicians use it for weight loss in patients without type 2 diabetes or those who do not meet the criteria for Wegovy.

Because Wegovy’s dosage strengths and titration schedule are specifically designed for obesity treatment and weight management, it is typically the first choice for individuals seeking a medication solely for obesity or overweight treatment. Rybelsus, on the other hand, might be chosen for patients whose priority is improving blood sugar control but who can also improve diabetes management with modest weight loss.

You did need a prescription for either drug. In order to get a prescription for Wegovy, you need to meet the criteria above. To be prescribed Rybelsus you usually need to be diagnosed with type 2 diabetes and with glucose levels and an A1C that meets the prescribing criteria for the medication.

 

2. Wegovy Vs Rybelsus: Dosage and Administration

The dosage and administration are another one of the key differences between these two drugs.

Wegovy

• Form: Subcutaneous injection (pen injector or standard syringes).
• Frequency: Once weekly.
• Titration: Typically starts at a lower dose (0.25 mg once weekly) and gradually increases to 2.4 mg once weekly maximum dose over about five months. This gradual escalation helps reduce gastrointestinal side effects.
• Patient Experience: Requires comfort with self-injecting. Some patients find weekly injections more convenient than daily oral medications because it’s a “set-and-forget” approach each week.

Rybelsus

• Form: Oral tablet.
• Frequency: Once daily.
• Dosages: Comes in 3 mg, 7 mg, and 14 mg tablets. Often, patients start at 3 mg daily, then may move to 7 mg, and potentially up to 14 mg to achieve better glucose control (and potentially more weight loss).
• Administration: Must be taken on an empty stomach upon waking, with a small amount of water (no more than 4 ounces). You should wait at least 30 minutes before eating or drinking anything else to ensure proper absorption.

Choosing between a weekly injection or a daily pill is often a matter of patient preference, lifestyle, and how the body tolerates each form. However, it is important to note that the effectiveness of oral semaglutide for weight loss has never been clinically tested.

3. Wegovy Vs Rybelsus: Cost

The cost of Wegovy versus that of Rybelsus can vary widely depending on location, insurance status, and available copay assistance programs. Below are some general considerations:

Wegovy

• Average List Price: Often around $1,300 or more monthly without insurance.
• Savings Programs: Some patients may qualify for manufacturer coupons or assistance if they meet certain insurance or income criteria, but these are often limited.

Rybelsus

• Average List Price: Typically around $900 to $1,000 for a 30-day supply without insurance (exact prices can vary).
• Savings Programs: Novo Nordisk often provides discount cards for those with commercial insurance. However, for Medicare or Medicaid patients, discount options can be more restrictive.

When weighing cost, remember that coverage of other than intended uses, like using Rybelsus purely for weight loss, might be denied by some insurance plans. Conversely, Wegovy may have better coverage if you meet the specific weight or health criteria.

4. Wegovy Vs Rybelsus: Insurance Coverage

As mentioned above, there could be significant differences between insurance coverage and the out-of-pocket costs for each of these medications.

Wegovy

• Insurance Coverage: Coverage for obesity medications varies. Some private insurers have recently expanded coverage for weight loss drugs due to the growing recognition of obesity as a chronic disease. However, others still exclude it or have strict prerequisites such as documented failure of diet/exercise programs, etc.
• Prior Authorization: Prior authorization is often needed, where your physician must submit documentation proving medical necessity.

Rybelsus

• Insurance Coverage: More commonly covered under prescription plans that cover diabetes medications, as it is FDA-approved for type 2 diabetes.
• Off-label Hurdles: If you do not have diabetes and want to use Rybelsus solely for weight management, insurance may not approve coverage. You could be responsible for the full out-of-pocket cost.

In both cases, it’s crucial to verify your coverage before starting the medication. Speak with your healthcare provider and consider reaching out to your pharmacy or insurance plan to clarify any coverage details and potential out-of-pocket expenses.

5. Wegovy Vs Rybelsus: Weight Loss Results

Of course, the greatest difference of note is how effective each of these drugs is for weight loss, as we have said of the two, and Wegovy has been clinically tested and approved for weight management in adults and teens.

Wegovy

• Clinical Trials: In its landmark clinic trial, participants lost, on average, around 15% of their baseline body weight (some lost even more) over 68 weeks when Wegovy was combined with lifestyle modifications such as increased physical activity and a healthy diet.
• Strength of Evidence: Because Wegovy is explicitly studied and approved for weight management, its dose (up to 2.4 mg weekly) is optimized for maximal weight loss. Wegovy has also been shown to improve heart health and lower the risk of heart attack or stroke.

Rybelsus

• Clinical Trials: Focus primarily on blood glucose control as a treatment of type 2 diabetes, but study participants also saw significant weight loss—ranging from about 3-5% to as high as 8-10% for some individuals on the higher doses (e.g., 14 mg daily).
• Off-label Weight Management: Many individuals do lose weight taking Rybelsus, but the total average loss is typically much less than what is observed with Wegovy’s higher semaglutide dosage. Oral semaglutide formulations were not intended for weight loss, and they have yet to be studied specifically for weight loss or as an obesity treatment.

Individual results vary widely. Factors like diet, exercise, underlying health conditions, and adherence all play a role in how much weight is ultimately lost.

6. Wegovy Vs. Rybelsus: Side Effects, Risks, Warnings and Adverse Effects

Since they contain the same active ingredient (semaglutide), generally speaking, the side effects for Wegovy and Rybelsus are pretty much the same, including the following issues and adverse events:

•  Gastrointestinal Side Effects: Nausea, vomiting, diarrhea, and constipation are the most commonly reported. Gradual dose escalation can help minimize these.
• Pancreatitis Risk: Although rare, GLP-1 receptor agonists can increase the risk of acute pancreatitis. Patients should seek medical attention for severe abdominal pain.
• Gallbladder Disease: Rapid weight loss or effects of GLP-1 medications can sometimes contribute to gallbladder issues such as gallstones.
• Thyroid Tumors in Animals: Semaglutide carries a boxed warning (severe side effects) about thyroid C-cell tumors observed in rodents, though it is unclear if this risk applies to humans. Still, those with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) are advised to avoid these medications.
• Hypoglycemia (Low Blood Sugar): More common when combined with other glucose-lowering medications like insulin or sulfonylureas.

Differences in Side Effects

• Injection vs. Oral: Wegovy (injectable) can cause local injection-site reactions. Rybelsus (oral) requires strict adherence to administration rules to reduce GI irritation and ensure absorption.
• Severity: Some patients find that the higher doses used in Wegovy can intensify GI side effects, whereas Rybelsus’ daily, lower-dose approach might cause milder but more consistent GI issues.

Always discuss your full medical history with your healthcare provider before starting any new medication, especially if you have a history of pancreatitis or thyroid nodules. Do not use either of these medications without a prescription and proper medical advice from a supervising healthcare professional.

7. How Do I Know Which Is Right for Me?

Now that you know how these drugs are the same and how they differ, deciding between Wegovy and Rybelsus can be complex, and no single answer fits everyone. However, the main deciding factor is your primary health goal. If your main objective is weight loss and you meet the BMI criteria (with or without additional health conditions), Wegovy will likely be the drug of choice for you as it is specifically approved and studied for this indication.

If you primarily need blood sugar control due to type 2 diabetes and could also benefit from some weight loss, Rybelsus is often the first-line oral semaglutide option. As a diabetes treatment, Rybelsus has been shown to lower A1C and provide some weight loss.

As noted above, Wegovy and all versions of semaglutide prescribed for chronic weight management are given via weekly injection. Rybelsus, on the other hand, is given in tablet form as a daily pill, so it could be a good option for people who need to lose weight but are entirely needle-phobic. Again, remember, Rybelsus was not meant to be prescribed solely for struggles with weight.

Ultimately, the best weight loss medication for you is the one that aligns with your medical history, health goals, and personal comfort. A thorough discussion with your doctor—possibly involving a dietitian or an endocrinologist—can help you make the most informed decision.

Now that you realize that of Wegovy and Rybelsus, only one is indicated for weight loss, why not Contact Us today and get started on Wegovy and a path to a slimmer, healthier you?

Dosing, administration instructions, warnings, and other product information are provided for informational purposes only and should not be construed as any kind of medical guidance or instructions for use. Consult your physician pharmacist or complete prescribing information for advice regarding your prescription for either Wegovy or Rybelsus.

Prices for prescription drugs are subject to change. Prices provided are for relative comparison purposes only and may not reflect the actual cost of either drug at the time of purchase.

Glucagon-like Peptide 1 agonists like Wegovy have become the rage in obesity control in recent years. However, they are not the only weight loss drugs healthcare professionals prescribe. How do they compare to their predecessors, like Phentermine?

Obesity is a significant health concern, and many individuals seek medical treatments to aid in weight loss and a reduction in body mass. Two common prescription drugs for shedding pounds are Wegovy and Phentermine. While both drugs help individuals who have struggled with weight gain slim down, they belong to two very different drug classes. They differ in their mechanisms of action, administration, cost, and overall effectiveness. Understanding these differences can help patients make informed decisions regarding their weight loss journey.

What Are Wegovy Injections?

Wegovy (semaglutide) is a revolutionary prescription medication approved for chronic weight management in individuals with obesity or overweight status who also have obesity-related medical conditions. It belongs to the class of drugs called GLP-1 receptor agonists (GLP1 Ras), which mimic the hormone glucagon-like peptide-1. This hormone helps regulate appetite and food intake by signaling to the brain that the body is full, thereby reducing hunger and promoting a lower calorie intake. Patients taking Wegovy injections feel full sooner and stay fuller longer. When combined with exercise and a low-calorie diet, people are losing 30 or 40 pounds or more in a relatively short time from Wegovy injections.

Wegovy is administered as a once-weekly subcutaneous injection. Weight loss results on Wegovy have been unprecedented in previous weight loss drugs like Phentermine. Wegovy and related medications represent a game-changing option for men and women who have struggled with obesity.

When combined with a healthy diet and increased regular exercise, people taking Wegovy have lost over 15% of their total body weight. In some individuals, that was 40 to 60 pounds!

Wegovy and its class of drugs have other benefits that drugs like Phentermine, which are basically stimulants, do not. For example, Wegovy can help lower blood pressure, decrease your level of “bad” cholesterol, and even lower your risk of developing heart disease or type 2 diabetes.

What is Phentermine?

Phentermine is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. That may sound similar to Wegovy, but these are two very different drugs with different mechanisms of action.

Phentermine was a popular weight loss drug before the introduction of GLP-1’s like Wegovy (semaglutide); since the introduction of Glucagon-Like Peptide 1 Receptor Agonists, it has been prescribed much less, as it has proven to be nowhere as effective as the newer GLP-1 RAs. However, Phentermine could be good for people who require temporary weight loss or are looking for a weight loss solution that could be considerably less expensive than Wegovy.

There is a version of Phentermine that is combined with another medication known as topiramate, and this combination is sold under the brand name “Qsymia.” But even in this combination, Phentermine offers only modest weight loss compared to Wegovy. In clinical trials, patients on Qsymia usually lose only about 5% to 7% of total body weight. It has the potential for some side effects that are significantly more serious than Wegovy and, therefore, is usually prescribed only for a few weeks, whereas Wegovy and similar drugs can be safely prescribed for years at a time.

The two drugs differ not only in their effectiveness but how long they can be taken. Because of the greatest risk of adverse effects and warnings about addiction, Phentermine can only be prescribed for a few months, whereas Wegovy is meant for long-term use. In clinical trials, the most significant weight reduction occurred after sixty-eight weeks!

What Are the Main Differences Between Wegovy and Phentermine?

While both medications can help reduce body fat, they differ significantly in their mechanisms of action, duration of use, and potential risks:

• Mechanism of Action: Semaglutide, the active ingredient in Wegovy mimics a natural hormone that regulates appetite, whereas Phentermine is a stimulant that suppresses hunger through increased neurotransmitter activity.
• Duration of Use: Wegovy is approved for long-term weight management, whereas Phentermine is intended for short-term use.
• Administration: Wegovy is an injectable medication taken once a week, while Phentermine is a daily oral medication.
• Regulatory Status: Phentermine is classified as a Schedule IV controlled substance due to its potential for abuse, whereas Wegovy is not.

Wegovy Vs Phentermine: Dosage and Administration

How these two drugs are taken is one of the major differences between the two.

• Wegovy: Delivered as a subcutaneous injection once a week, with a gradually increasing dosage schedule to minimize gastrointestinal side effects.
• Phentermine: Take it orally once daily in tablet or oral capsule form, with the dosage depending on individual patient needs.

While much less effective for weight loss and with some greater potential for abuse and adverse events, Phentermine could be a good Wegovy alternative for people with a fear of needles.

Wegovy Vs. Phentermine: Cost

The relative cost of Wegovy versus Phentermine is another big variant between the two drugs.

• Wegovy: Typically costs between $1,300 and $1,500 per month without insurance.
• Phentermine: Generally much more affordable, costing between $10 and $50 per month.

Wegovy Vs Phentermine: Insurance Coverage

Insurance coverage for Wegovy and other weight loss drugs is constantly evolving. As of this writing:

• Wegovy: This may be covered by insurance for patients meeting specific criteria related to obesity and weight-related health conditions, though prior authorization is often required.
• Phentermine: Often covered by insurance, but coverage may be limited due to its classification as a short-term weight loss drug.

Wegovy Vs. Phentermine: Weight Loss Results

Now for the million-dollar question, “Which one is more effective for weight loss, Wegovy or Phentermine?” There really is no comparison; hands down, Wegovy is far more effective for sustainable weight loss than Phentermine, even in its combo form, Qsymia.

• Wegovy: Clinical trials show an average weight loss of as much as 16% of body weight over 68 weeks after reaching the maximum dose.
• Phentermine: Studies indicate an average weight loss of only about 5-10% over a few months.

Wegovy Vs. Phentermine: Side Effects, Risks, Warnings and Adverse Effects

Another large variance between the two anti-obesity medications is their safety profile. Wegovy, generally speaking, is a much safer option than Phentermine.

• Wegovy: Common side effects of semaglutide in adults include nausea, vomiting, diarrhea, constipation, and potential pancreatitis or gallbladder issues.
• Phentermine: Side effects include increased heart rate, elevated blood pressure, insomnia, nervousness, and the potential for dependence, especially in persons with a history of drug abuse.

How Do I Know Which Is Right for Me?

On almost every count, Wegovy is a better choice for safe, sustainable weight loss and chronic weight management than Phentermine. Wegovy has fewer potential side effects and also can reduce your risk of cardiovascular disease and help control blood sugar. Phentermine does none of that.

Still, those who may be looking for short-term assistance with weight loss and who are not at risk for stimulant-related side effects might consider Phentermine. However, only you and your medical professional can make a decision on which is right for your particular struggle with obesity. Do not use either of these medications without a prescription and proper medical advice.

At Wegovy Weight Loss, we are out on the cutting edge of medical weight loss and have helped hundreds of men and women just like you finally achieve their long-term weight loss goals with a specialized Wegovy treatment plan. Why don’t you Contact Us today to find out more about safe and effective medical weight loss with Wegovy?

Both Wegovy (semaglutide) and Tirzepatide have been used for chronic weight management and to treat obesity. Both medications began their lives as medications to treat people with type 2 diabetes, Ozempic and Mounjaro, respectively. Semaglutide was the first drug of this kind to be approved for weight loss and chronic weight management; it has since been sold under the brand name Wegovy. Tirzepatide was approved for weight management in November 2023 and has since been sold under the brand name Zepbound. Mounjaro, while the same medication (Tirzepatide) is still prescribed for people with Type 2 diabetes.

In addition to weight loss, both drugs are very good at controlling blood sugar levels, which can help adults with obesity not only slim down but lower their risk of developing diabetes.

These are both very similar prescription medications and have many things in common in terms of effectiveness for weight loss, mechanisms of action, and side effects. Health insurance coverage may or may not be available for either weight loss drug. However, despite sharing many commonalities, they are not the same thing and do have some key differences.

Both drugs belong to a class of groundbreaking weight loss drugs known as GLP-1 receptor agonists, or more simply “GLP-1s.” GLP-1 agonists work by mimicking glucagon-like peptide-1 (GLP-1), a natural hormone that is involved in regulating blood glucose levels as well as how long food remains in your stomach. Therefore, these drugs can be effective for weight loss by improving metabolism and reducing body mass by impacting hunger, digestion, and feelings of fullness. Both Tirzepatide and Wegovy are given via a once-weekly subcutaneous injection.

Both are indicated for people who are obese or overweight and who are suffering from other health conditions impacting metabolism and heart health. Let’s take a close look at what the two weight loss medications have in common and where they differ.

 

The Five Most Important Differences Between Tirzepatide and Wegovy

Wegovy is made by Novo Nordisk. Tirzepatide (Zepbound/Mounjaro) is made by Eli Lilly. They are similar drugs with several significant differences.

Difference 1: How They Work

• Wegovy: Semaglutide, the active ingredient in Wegovy, belongs to the class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. GLP-1 is a hormone that regulates blood sugar levels and appetite. Semaglutide stimulates GLP-1 receptors in the brain, leading to decreased appetite, increased feelings of fullness, and reduced food intake. Additionally, it slows down stomach emptying, which further contributes to the sense of satiety.
• Tirzepatide: Tirzepatide, the primary component of Tirzepatide, is a novel medication that combines the actions of GLP-1 and glucose-dependent insulinotropic peptide (GIP) receptor agonists. Unlike Wegovy and other GLP-1s, this dual mechanism mimics the action of two hormones and targets specific pathways to regulate blood sugar and appetite. Like semaglutide, tripeptide also reduces appetite, increases satiety, and delays stomach emptying.

 Difference 2: Effectiveness for Weight Loss and Who Are They Prescribed For

• Wegovy: Wegovy has undergone drug trials involving participants both with and without diabetes. During clinical trials, adults taking Wegovy lost as much as 15% of their total body weight. In a separate trial, adolescents lost about 16% of their starting body weight on average. Wegovy is indicated for use in adults and children 12 years and older with obesity or excess weight and weight-related health problems such as high blood pressure or high cholesterol.
• Tirzepatide –The preliminary approval studies of Tirzepatide for obesity control seemed to indicate that it could be somewhat more effective than Wegovy. In studies of Tirzepatide, participants taking the highest 15 mg dose lost 20% of their body weight in about the same time period that patients on Wegovy lost about 15%. Tirzepatide is prescribed for people with obesity or people who are overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high blood cholesterol.

Keep in mind that either drug is not merely an “appetite suppressant” or any kind of “diet pill” but a serious prescription drug researched and developed for medical weight loss purposes in specific target populations. Tirzepatide, in particular, has a unique mechanism of action and target audience among the class of GLP-1 agonists since it is the only one that also acts as a (GIP) receptor agonist.

Difference 3: Comparative Usage and Dosage*

Both Tirzepatide and Wegovy are given as a subcutaneous injection using a pen-like injector device. To give this type of injection, you start by sterilizing the injection site with an alcohol swab. Then, pinch a fold of skin at the cleaned injection site to create a small area of tissue. Remove the cap of the injector pen of either device and carefully insert the needle into the fold of the skin at a 90-degree angle or as directed by your healthcare provider. Push the plunger down to inject the medication.

Either drug can be taken any time of day or night with or without food; the key is that you take your once-weekly injection at the same time each week.

A typical Wegovy dosage schedule for weight loss is:

• First Month: 0.25 mg once weekly (starting dosage)
• Second Month: 0.5 mg once weekly
• Third Month: 1 mg once weekly
• Fourth Month: 1.7 mg once weekly
• Fifth Month: 2.4 mg once weekly (target dosage)

Like Wegovy, Tirzepatide is titrated, meaning your doctor will start you out at the lowest possible dose and slowly increase to the maximum effective dosage for weight loss.

Typically, the starting dosage of Tirzepatide is 2.5 mg. In addition to the starting dose, Tirzepatide is available in 7.5 mg, 10 mg, 12.5 mg, and 15 mg. Similar to Wegovy, your doctor will probably increase your dosage monthly until you build to the maximum dose. In clinical trials, optimal weight loss was seen in patients on the 15mg dose of Tirzepatide.

Difference 4: Cost**

Both Wegovy and Tirzepatide are on the expensive side as prescription drugs go. But of the two, Wegovy is more expensive, with an average price of around $1600** for a one-month supply, whereas Tirzepatide is about $1100**.

Health insurance coverage may impact the cost of Wegovy of Zepbound. The price you pay for either drug will vary depending on your insurance plans, your healthcare provider, and your pharmacy.

Difference Five: Relative Weight Loss Results

Tirzepatide and Wegovy work by mimicking the action of certain naturally occurring hormones that are involved in appetite and glucose metabolism. While the biological impact is similar, Wegovy and Tirzepatide act somewhat differently because they mimic the effects of different hormones. Wegovy mimics the action of GLP-1. Tirzepatide also acts like GLP-1 in the body, but in addition, it mimics the action of another hormone that Wegovy does not, known as GIP.

The actions of both of these naturally occurring hormones and the drugs that mimic them can make you feel fuller quicker and longer, which can curb appetite and help you lose weight.

In the initial trials, Tirzepatide seemed to be somewhat more effective for weight loss than Wegovy. People receiving the highest Tirzepatide –15 mg — lost nearly 21% of their starting body weight on average. What’s more, almost 60% of participants in this group lost 20% or more of their body weight. In its initial approval trials, the maximum weight loss on Wegovy was 16% of the participant’s total starting body weight.

Head-to-head trial clinical studies are currently underway, and while it will still be some time before these are concluded, early results do show greater average weight loss with Zepbound compared with Wegovy – 20% in overall body weight loss versus 14% for Wegovy at 72 weeks in participants with obesity without diabetes.

It is important to note that on either medication, maximum weight loss was achieved with proper diet, reduced caloric intake, and increased physical activity,

Do Wegovy and Tirzepatide Have the Same Side Effects?

All weight loss medications in this drug class (GLP-1 RA), including Wegovy and Tirzepatide, have the same general side effects or adverse reactions. The most common side effect is injection site reactions. Other common side effects include:

• Abdominal pain
• Nausea
• Vomiting
• A potential for hair loss
• Gas
• Bloating

Other less common side effects that have been reported include an increased risk of chronic kidney disease, liver issues, or pancreatitis.

Wegovy Versus Tirzepatide Other Differences

Besides the five major differences between Wegovy and Tirzepatide discussed above, there are a few other differences between the two. Wegovy might be better for you if you have heart disease or are predisposed to cardiovascular disease. Since its approval for weight management, Wegovy (semaglutide) has also been approved to reduce the risk of heart failure and other forms of cardiovascular disease. Tirzepatide is in clinical trial for similar approval, but for now, it is only prescribed as a weight loss drug. Also, Wegovy can be prescribed for adolescents 12 and over, and Tirzepatide currently can only be used by adults over 18.

Only your healthcare provider can decide which drug is better for you based on your unique circumstances and weight loss goals. However, if you are interested in Wegovy, we have Wegovy injections available, and you can get started today on a path to remarkable weight loss by Contacting Us.

Now that you know more about semaglutide treatment with Wegovy, why not Contact Us today and learn more about the life-changing benefits of GLP-1’s for Weight Loss?

*Dosing, administration instructions, warnings, and other product information are provided for informational purposes only and should not be construed as any kind of medical guidance or instructions for use. Consult your physician pharmacist or complete prescribing information for advice regarding your prescription for Wegovy or Tirzepatide.

** Prices for prescription drugs are subject to change. Prices provided are for relative comparison purposes only and may not be a reflection of the actual cost of either drug at the time of purchase.

Zepbound vs. Wegovy: How Do They Compare?

Both Wegovy (semaglutide) and Zepbound (tirzepatide) have been approved for weight management and for treating obesity. They are quite effective medications with many things in common regarding effectiveness, mechanisms of action, and side effects. However, they are not the same; while they are prescribed to treat the same health conditions, each name-brand drug has a different active ingredient.

Both are injectable medications belonging to a class of drugs known as GLP-1 agonists. These drugs work by mimicking glucagon-like peptide-1 (GLP-1), a natural hormone involved in regulating blood glucose levels and the length of time food remains in the stomach. Therefore, these drugs can be effective for weight loss by improving metabolism and impacting hunger, digestion, and feelings of fullness. While individual responses will vary, average weight loss has been impressive on both medications.

Because of the way this class of drugs affects both insulin and hunger, both semaglutide and tirzepatide started out as medications to treat adults with type 2 diabetes – Ozempic and Mounjaro, respectively. Wegovy and Zepbound are the brand names of the drugs prescribed specifically for weight loss.

Both Zepbound and Wegovy are given a once-weekly subcutaneous injection. Let’s examine what the two drugs have in common and where they differ.

The Main Differences Between Zepbound and Wegovy

Wegovy is made by Novo Nordisk. Zepbound is made by Eli Lilly. They are similar drugs yet with several significant differences.

Mechanisms of Action

Wegovy: Semaglutide, the active ingredient in Wegovy, belongs to the class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. GLP-1 is a hormone that regulates blood sugar levels and appetite. Semaglutide stimulates GLP-1 receptors in the brain, leading to decreased appetite, increased feelings of fullness, and reduced food intake. Additionally, it slows down stomach emptying, which further contributes to the sense of satiety.

Zepbound: Tirzepatide, the primary component of Zepbound, is a novel medication that combines the actions of GLP-1 and glucose-dependent insulinotropic peptide (GIP) receptor agonists. Unlike Wegovy and other GLP-1s, this dual mechanism mimics the action of two hormones and targets specific pathways to regulate blood sugar and appetite. Like semaglutide, tripeptide also reduces appetite, increases satiety, and delays stomach emptying.

Prescribed Populations

Wegovy and Zepbound have both been prescribed for weight loss, but they do have somewhat different purposes and target populations. Your medical history and health goals will help determine what is right for you.

• Wegovy: Wegovy is approved for individuals with a body mass index (BMI) of 30 or higher or those with a BMI of 27 or higher who have at least one weight-related comorbidity, such as diabetes, high blood pressure, or high cholesterol.
• Zepbound: Zepbound is also indicated for individuals with a BMI of 30 or higher or those with a BMI of 27 or higher with at least one weight-related comorbidity. However, its original approval was for individuals with type 2 diabetes to help manage their blood sugar levels and promote weight loss, which can improve symptoms and complications of diabetes.

Effectiveness for Weight Loss

• Wegovy: Wegovy has undergone drug trials involving participants with and without diabetes. During clinical trials, adults taking Wegovy lost as much as 15% of their total body weight. In a separate trial, adolescents lost an average of about 16% of their starting body weight.
• Zepbound: The preliminary approval studies of tirzepatide for obesity control indicated that it could be somewhat more effective than Wegovy. In studies of Zepbound, participants taking the highest 15 mg dose lost 20% of their body weight in about the same time period that patients on Wegovy lost about 15%.

Keep in mind that either drug is not merely an “appetite suppressant” or any kind of “diet pill” but a serious prescription drug researched and developed for medical weight loss purposes in specific target populations. Zepbound, in particular, has a unique mechanism of action and target audience among the class of GLP-1 agonists since it is the only one that also acts as a (GIP) receptor agonist.

Legality of Use and Availability

Since 2021, Wegovy has been approved for weight loss in adults and children 12 and older who meet certain criteria. In November 2023, Zepbound was approved for the same purposes and with similar prescribing criteria.

Wegovy, since it has been on the market longer, is the most popular medication in this class of weight loss drugs. It has become very well-known, and availability is sometimes low, but Novo Nordisk has been ramping up drug production to meet the increased demand. Because of the popularity of Wegovy, it may be easier to get a prescription for Zepbound. However, it is not for everyone and should be prescribed with discretion for weight loss; speak to your doctor to see if Zepbound is right for you.

Comparative Usage and Dosage*

Both Zepbound and Wegovy are given as a subcutaneous (below the skin) injection using a pen-like injector device. To give this type of injection, you start by sterilizing the injection site with an alcohol swab. Then, pinch a fold of skin at the cleaned injection site to create a small tissue area. Remove the cap of the injector pen of either device and carefully insert the needle into the fold of the skin at a 90-degree angle or as directed by your healthcare provider. Push the plunger down to inject the medication.

Either drug can be taken any time of day or night with or without food; the key is that you take your once-weekly injection at the same time each week.

A typical Wegovy dosage schedule for weight loss is:

• First Month: 0.25 mg once weekly (starting dosage)
• Second Month: 0.5 mg once weekly
• Third Month: 1 mg once weekly
• Fourth Month: 1.7 mg once weekly
• Fifth Month: 2.4 mg once weekly (target dosage)

Like Wegovy, Zepbound is titrated, meaning your doctor will start you out at the lowest possible dose and slowly increase to the maximum effective dosage for weight loss.

Typically, the starting dose of Zepbound is 2.5 mg. In addition to the starting dose, Zepbound is available in 7.5 mg, 10 mg, 12.5 mg, and 15 mg. Similar to Wegovy, your doctor will probably increase your dosage monthly until you reach the maximum dose. In clinical trials, optimal weight loss was seen in patients on the 15mg dose of Zepbound.

Insurance coverage

Insurance coverage of Wegovy and Zepbound will vary from insurance plan to insurance plan. While it is changing, many insurers are still hesitant to provide coverage for drugs that are specifically prescribed for weight loss. Depending on your insurance and your circumstances, you may be covered for one, both, or neither of these medications.

It is always a good idea to check with your healthcare plan before speaking to your doctor about prescription options for weight loss to see what may or may not be covered.

The makers of both Wegovy and Zepbound offer patient assistant savings programs for people with commercial or private insurance. You may be eligible even if your plan does not cover Wegovy or Zepbound.

Relative Weight Loss Results

Either Zepbound or Wegovy is indicated for the treatment of obesity.

While the biological impact is similar, Wegovy and Zepbound act somewhat differently because they mimic the effects of different hormones. Wegovy mimics the action of GLP-1. Zepbound also acts like GLP-1 in the body, but it also mimics the action of another hormone that Wegovy does not, known as GIP.

The actions of both of these naturally occurring hormones and the drugs that mimic them can make you feel fuller quicker and for longer, curbing your appetite and helping you lose weight.

As mentioned earlier, one of the early clinical trials looking at Zepbound for weight loss found that it is potentially more effective at its maximum dose than Wegovy, particularly in patients who are both overweight and have type 2 diabetes. These studies indicate that Zepbound may result in greater weight loss than Wegovy, so if you need more help managing your weight, Zepbound could be the better choice. However, there is also clinical evidence to indicate that semaglutide may be more effective in lowering your risk of heart disease or adverse cardiovascular events like stroke or heart attack than tirzepatide.

Only your healthcare provider can decide which drug is better for you based on your unique circumstances and weight loss goals.

 

Side Effects

The most common side effect with either drug is injection site reactions. As to other relative side effects, since both drugs work to some degree on digestion, they have very similar side effects that are mostly related to stomach upset and gastric distress. The most common side effects of both drugs are:

• Nausea.
• Vomiting.
• Gas and bloated stomach
• Indigestion.
• Diarrhea.
• Constipation.
• Abdominal pain.
• Upset stomach.

Severe side effects such as kidney, liver, or gallbladder issues are rare but have been reported on both medications, so you must tell your doctor if you or anyone in your family has had a history of any such conditions.

Since the most common side effects of Wegovy and Zepbound are so similar, and your risk of adverse effects will be based on your particular tolerances or sensitives to the active ingredients in either drug, it’s hard to say which drug may cause you more or fewer issues,

If you would like to know more about Wegovy medical weight loss, how it compares to Zepbound, or any other information about this remarkable breakthrough in weight management, please do not hesitate to Contact Us. We are here to help.

*Dosing, administration instructions, warnings, and other product information are provided for informational purposes only and should not be construed as any kind of medical guidance or instructions for use. Consult your physician pharmacist or complete prescribing information for advice regarding your prescription for Wegovy or Zepbound.

** Prices for prescription drugs are subject to change. Prices provided are for relative comparison purposes only and may not reflect the actual cost of either drug at the time of purchase.

Wegovy versus Ozempic for Better Weight Loss

Both Wegovy and Ozempic belong to the same class of drugs, GLP-1 receptor antagonists. They both contain the same active ingredient, semaglutide. They both work the same way as all GLP-1 receptor agonists. These drugs work by mimicking – the action of hormones related to hunger, feeling full, and sugar metabolism.

While there are many similarities between Wegovy and Ozempic, they are not the same thing, nor are they interchangeable. While both drugs have raised excitement for their potential to and in weight loss, only one Wegovy is actually prescribed for weight loss, and the drugs are also distinct in their applications and potential benefits.

Main Differences Between Ozempic and Wegovy

Wegovy and Ozempic are both made by the same pharmaceutical company, Novo Nordisk. While they both contain the same active ingredient, semaglutide, they each contain different dosages. Ozempic is approved to treat Type 2 diabetes, trials show that Ozempic use as a diabetes treatment helped patients to lose weight. Wegovy is a higher-dose version that’s approved for weight loss.

Here are some more details of the main differences between Ozempic and Wegovy.

Mechanism of Action

Wegovy works by mimicking the effects of GLP-1 in the body, which leads to increased feelings of fullness, reduced appetite, and slowed digestion. This, in turn, can result in decreased food intake and weight loss.

Similar to Wegovy, Ozempic is also a GLP-1 receptor agonist that contains semaglutide. It operates by increasing insulin secretion in response to food consumption and reducing the production of glucagon, a hormone that raises blood sugar levels.

Target Audience

Wegovyp is primarily recommended for individuals with a Body Mass Index (BMI) of 27 or higher, who have at least one weight-related condition, or those with a BMI of 30 or higher. Wegovy is also approved for weight management in adolescents ages 12 and older. In order to be eligible, adolescents must have a BMI at or above the 95th percentile for their age and sex.

Ozempic is originally designed for people with type 2 diabetes. Adults with Type 2 diabetes may be prescribed Ozempic to help balance blood glucose levels. If you’ve been prescribed Ozempic and don’t have diabetes, this is considered “off-label” use. Unlike Wegovy, Ozempic is not approved for use of any kind for people less than 18 years of age – another distinction between the two medications.

Effectiveness for Weight Loss

Wegovy has undergone drug trials involving participants both with and without diabetes. During clinical trials, adults taking Wegovy lost as much as 15% of their total body weight. In a separate trial, adolescents lost about 16% of their starting body weight on average.In a clinical trial comparing the maximum weekly dose of Ozempic vs. Wegovy, Wegovy caused more weight loss than Ozempic.

Again, Ozempic is usually not prescribed for weight loss. Ozempic’s weight loss benefits make it a good drug of choice for patients with type 2 diabetes who are also overweight. However, for non-diabetics who are struggling with obesity, Wegovy is the better choice as its dosage of semaglutide has been optimized for weight management, and this is what the drug has been studied and approved for.

As you can see from the above list of significant differences, Wegovy and Ozempic are not merely “appetite suppressants” or any kind of “diet pills” but serious prescription drugs researched and developed for two distinct purposes and quite specific target populations.

 Legality of Use 

Wegovy and Ozempic are both FDA-approved but for different purposes. While you can take either drug with or without having diabetes, Wegovy is specifically approved for chronic weight management in adults with obesity or those who are overweight and have at least one weight-related condition (e.g., high blood pressure, type 2 diabetes). It is also approved for adolescents and teens over 12 who have a BMI at or above the 95th percentile for their age and sex.

Ozempic was initially approved as a treatment for type 2 diabetes, as it helps regulate blood sugar levels. During Ozempic’s clinical trials, participants lowered their A1C by over 1%. A1C is your average blood glucose level over three months.

FDA has approved the prescription of Ozempic for controlling blood sugar in adults over 18 years old with type 2 diabetes mellitus and for reducing the risk of cardiovascular incidents such as heart attack and stroke in adults with type 2 diabetes and heart disease.

While it is legal to use Ozempic for weight loss, the more effective drug is Wegovy, and since it is prescribed for this purpose, it is often easier to get Wegovy for weight loss than Ozempic.

Usage

Wegovy is prescribed for adults and adolescents over 12 for weight loss who meet certain criteria, as mentioned above.

Ozempic is prescribed for the control of type 2 diabetes and is only recommended for weight loss in people with diabetes who are also struggling with obesity.

Dosage

Ozempic and Wegovy are both taken as a once-weekly subcutaneous injection. They come in a premeasured injectable pen device, so it is very easy for you to give yourself your injections at home.

A subcutaneous injection means that the drug is injected just below the surface of the skin, usually in a fatty area of the body, such as the upper thigh or abdomen. The injection is very shallow, and the needle in the injector is quite small and thin, so the injection is painless for most patients.

In giving the subcutaneous injection of either drug, you start by making sure your injection site is completely sterile by rubbing it down with an alcohol swab.

Wait for the area to dry completely, then remove the cap from your Wegovy or Ozempic pen and pinch a fold of skin at the injection site to create a small area of tissue.

Insert the needle into the fold of the skin at a 90-degree angle or as directed by your healthcare provider. Push the plunger down to inject the medication.

Either drug can be taken any time of day or night with or without food. The key is that you take your injection at the same time of day or night consistently.

While Ozempic and Wegovy are given the same way, the dosages are quite different. Each drug is titrated, which means you start out at the least effective dose and slowly increase your dosage over time.

A typical Wegovy dosage schedule is:

• First Month: 0.25 mg once weekly (starting dosage)
• Second Month: 0.5 mg once weekly
• Third Month: 1 mg once weekly
• Fourth Month: 1.7 mg once weekly
• Fifth Month: 2.4 mg once weekly (target dosage)

A typical Ozempic dosage schedule is:

• First Month: 0.25 mg once weekly (starting dosage)
• Second Month: 0.5 mg once weekly

If needed, your Ozempic dosage may be increased up to the maximum dosage, which is 2.5 mg once weekly.

Costs

The cost of either medication will vary based on factors such as location, insurance coverage, and the specific pharmacy where your prescription is filled. Since it contains a lower dose of semaglutide, Ozempic costs less than Wegovy. The average monthly cost of Ozempic is about $900, with Wegovy being around $1600.

Insurance Coverage

Wegovy and Ozempic may be covered differently under your insurance plan. Wegovy for weight loss may or may not be covered by insurance.

Before providing coverage for Wegovy, your insurance company may ask that you prove you have tried other weight management methods and failed before being prescribed Wegovy.

Your insurer may also require that Wegovy is prescribed as part of some kind of overall “medical weight loss program” before providing any coverage.

When Ozempic is prescribed as approved for patients with diabetes, it is almost always covered by insurance. However, since prescribing Ozempic for weight loss is an “off-label” use, it is unlikely to be covered by insurance.

Therefore, if your goal is to have your weight loss medication covered in whole or in part by health insurance, then you are more likely to be covered if you are prescribed Wegovy.

If you have commercial insurance, you may be able to save on your prescription for either medication with a savings card from the manufacturer. That means you could pay as little as $25 for Wegovy and as little as $25 for Ozempic.

Patient assistance programs are also available from Novo Nordisk for both medications.

Results

Users need to understand that it takes time to see the full results that can be achieved on either Wegovy or Ozempic.

Wegovy is most effective at its maximum dose. However, it can take up to five months before you are prescribed the maximum dose of Wegovy. The starting dosage of Ozempic of 0.25 mg weekly is also quite very low, and it takes even longer for you to see results on Ozempic, even of glucose control, let alone weight loss.

Comparing the results of the two, you will always achieve greater weight loss on Wegovy because it is indicated for weight loss, and it has a higher dose of semaglutide.

Side Effects

Both Wegovy and Ozempic have similar side effects, the most common of which are gastrointestinal issues such as nausea, bloating, gas, indigestion, vomiting, stomach pain, or diarrhea. Since Wegovy contains a higher dose of the active ingredient, the risk of these and other potential side effects is higher with Wegovy than with Ozempic.

*Dosing, administration instructions, warnings, and other product information are provided for informational purposes only and should not be construed as any kind of medical guidance or instructions for use. Consult your physician, pharmacist, or full prescribing information for guidance regarding your particular prescription for Wegovy or Ozempic.

How to Optimize Your Weight Loss On Wegovy?

Wegovy is a very good treatment option for controlling body weight, but there are lifestyle modifications you can and should do to maximize Wegovy weight loss.

Wegovy (semaglutide) is an FDA-approved medication for weight loss that has shown promising results as a long-term treatment for individuals struggling with obesity. However, achieving optimal weight loss with Wegovy requires more than just taking the medication; it involves a holistic approach combining the drug with a low-calorie diet, regular exercise, and healthy lifestyle choices.

Wegovy mimics a natural hormone called GLP-1 (glucagon-like peptide-1), which regulates appetite and feelings of fullness, reducing food intake. While the medication effectively curbs cravings and helps you feel full, clinical studies have found that this weight loss medication works best when paired with intentional lifestyle changes, including improved exercise habits, dietary changes, and other strategies to help you succeed in your weight loss journey.

Best Exercises and Workouts While Taking Wegovy

Exercise is vital to any weight loss plan, as it helps burn calories, build muscle, and improve overall health. Here are some of the best exercises to pair with GLP-1 medications for optimal results.

1. Aerobic Exercise (Cardio)

Cardio exercises like walking, jogging, swimming, and cycling effectively burn calories and improve cardiovascular health. Starting your daily routine with moderate cardio, such as brisk walking or cycling, for at least 150 minutes per week is a good goal. As you progress, you can increase the duration and intensity.

2. Strength Training

Strength training exercises help preserve and build muscle, essential for maintaining a healthy metabolism during weight loss. Strength training exercises like weightlifting, resistance band workouts, or body-weight exercises (such as push-ups and squats) benefit your Wegovy weight loss outcome. Aim for at least two days of weekly strength training to maximize fat loss and improve body mass composition.

3. High-Intensity Interval Training (HIIT)

HIIT workouts alternate between short bursts of intense activity and periods of rest or low-intensity exercise. Studies have shown that HIIT can be highly effective in helping you hit your weight goals on Wegovy. If you’re new to this exercise routine, consider starting with low-impact HIIT routines that alternate between brisk walking and faster-paced intervals.

4. Flexibility and Balance Exercises

Incorporating flexibility and balance exercises, like yoga or Pilates, can improve your range of motion, reduce stress, and lower your risk of injury. These practices can complement your overall workout plan, enhancing mobility and supporting a well-rounded fitness regimen.

Can Wegovy Be Used for Bodybuilding?

While Wegovy is effective for weight loss, it is not a bodybuilding or muscle gain prescription. Semaglutide’s primary function is to regulate appetite, helping individuals to eat less and lose weight. This appetite-suppressing effect may hinder calorie intake for bodybuilders, which is essential for muscle growth.

That said, some people use Wegovy as part of a cutting phase to reduce body fat. However, if muscle gain is your primary goal, Wegovy may not be the ideal medication due to its appetite-reducing effects. For individuals interested in weight loss while maintaining lean muscle, it’s essential to incorporate protein-rich foods and adequate strength training into their routine.

Best Diets for Wegovy – What to Eat and What Not to

Eating a healthy diet while taking Wegovy is essential for maximum weight reduction. The best diet to eat while taking Wegovy includes foods that are lower in calories, saturated fats, and sugars and high in lean protein and other essential nutrients. Such a diet will help you get the most out of taking Wegovy. Here are some of the other benefits of eating right while on Wegovy.

1. Improved nutrient intake: Weight loss drugs like Wegovy can reduce appetite but don’t provide essential nutrients. A healthy diet ensures your body receives the necessary vitamins, minerals, and nutrients to maintain good health. Nutrient deficiencies can occur if you rely solely on the drug and neglect your diet. Studies have found that increasing your protein intake is very important while taking weight loss injections.
2. Sustainable weight loss: Weight loss drugs can be effective in the short term but may not provide lasting results. Incorporating healthy eating habits into your lifestyle makes you more likely to sustain your weight loss over time. This is essential for preventing weight regain once you stop taking the medication.
3. Health benefits beyond weight loss: A healthy diet offers numerous benefits, such as improved cardiovascular health, better blood sugar control, and reduced risk of chronic diseases like diabetes and heart disease. Combining Wegovy with a nutritious diet can help you better manage blood sugar levels, control blood pressure, increase metabolism, and contribute to overall well-being.
4. Side effect management: Like any medication, Wegovy may have side effects, including nausea, diarrhea, and changes in appetite. A healthy diet can help manage these side effects. For example, eating smaller, more frequent meals can alleviate nausea, and a fiber-rich diet can help with digestive issues.

What Not To Eat While on Semaglutide

To maximize the effectiveness of Wegovy, it’s crucial to avoid certain foods. Here is a detailed list of foods to avoid, along with reasons why they should be eliminated from your diet and healthier alternatives:

Highly Processed Foods

Avoid foods high in added sugars, refined grains, and unhealthy fats. These can lead to excessive calorie intake and insulin spikes. Instead, opt for whole foods like fruits, vegetables, and whole grains.

Fried Foods

Fried foods are typically high in unhealthy fats and calories. Opt instead for baked, grilled, or steamed options for a healthier choice.

Sugary Beverages

Sugary drinks like soda, fruit juices, and energy drinks can contribute to weight gain. Choose water, herbal tea, or sparkling water with no added sugar.

Fast Food

Fast food is often loaded with calories, unhealthy fats, and sodium. Cook homemade meals with lean proteins, vegetables, and whole grains instead.

Sweets and Desserts

High-calorie desserts and sweets should be limited. Choose fruit or yogurt as a healthier alternative when you have a sweet craving.

Alcohol

Alcohol contains empty calories and can impair your judgment, leading to poor food choices. If you drink, do so in moderation and choose lower-calorie options.

High-Carb, Low-Nutrient Foods

Foods like white bread, white rice, and sugary cereals can cause blood sugar spikes and crashes. Instead, choose whole-grain alternatives for better blood sugar control.

What to Eat When Taking Wegovy

Here’s a sample diet plan to follow while taking Wegovy. Please consult with our medical team for personalized recommendations based on your specific needs and goals:

Breakfast

• Scrambled eggs with spinach and tomatoes
• Whole-grain toast
• A serving of mixed berries

Lunch

• Grilled chicken salad with mixed greens, cherry tomatoes, and vinaigrette dressing
• Quinoa or brown rice on the side

Snack

• Greek yogurt with a drizzle of honey and a handful of almonds

Dinner

• Baked salmon with asparagus and quinoa
• Steamed broccoli or green beans

Snack (if needed)

• Sliced cucumber with hummus

Working with our medical team to determine your specific calorie needs is essential. However, a general guideline for daily caloric intake while taking Wegovy is typically around 1,200 to 1,500 calories daily.

Other Ways to Maximize Wegovy Weight Loss

Alongside diet and exercise, lifestyle habits and supportive treatments can further enhance your weight loss journey with anti-obesity medication like Wegovy.

1. Set Realistic Goals and Track Progress

Realistic, achievable weight loss goals can keep you motivated. Setting a target, such as aiming for 1 to 2 pounds of weight loss per week, is realistic and healthy. Many people find it helpful to keep track of their progress through weekly weigh-ins and measurements or by documenting changes in energy levels, mood, and overall well-being.

2. Practice Mindful Eating

Wegovy helps reduce hunger and cravings, but adopting mindful eating practices can further enhance its effects. Pay attention to hunger and satiety cues, chew food thoroughly, and savor each bite. Avoid distractions like television or phones while eating to help prevent overeating.

3. Establish Consistent Sleep Patterns

Getting enough quality sleep is crucial for weight management. Poor sleep disrupts hunger-regulating hormones, increasing cravings for high-calorie foods. Aim for 7-9 hours of sleep per night and maintain a consistent sleep schedule.

4. Manage Stress

Chronic stress triggers the release of cortisol, a hormone linked to increased fat storage, particularly around the abdomen. Reducing stress levels with stress management techniques, such as deep breathing exercises, meditation, and regular physical activity, can reduce cortisol levels and support your weight loss efforts.

5. Track Your Progress

Tracking your food intake, exercise, and mood can help you stay accountable and motivated. Many people find success using mobile apps or journals to monitor their habits and identify patterns that may be affecting their weight loss.

6. Seek Support from Healthcare Professionals

Regular check-ins with a healthcare provider or registered dietitian can provide valuable guidance and encouragement. They can help tailor your diet, adjust your exercise plan, and offer advice for overcoming any challenges you encounter.

7. Consider Behavioral Therapy

In addition to adopting a balanced diet and getting more exercise, some people may benefit from behavioral therapy or counseling, particularly if emotional eating or other behaviors hinder their long-term weight loss. Behavioral therapy can teach strategies for managing cravings, reducing emotional eating, and building healthier habits.

Getting the Best Weight Loss Results From Wegovy: Conclusion

Wegovy offers a promising avenue for weight loss. Still, for the best results and to optimize health and control weight-related medical conditions, it’s essential to combine the medication with healthy lifestyle choices. Regular exercise, a nutrient-dense, reduced-calorie diet, and supportive lifestyle habits can help maximize your results and sustain long-term weight management.

By following the tips outlined above, you can make the most out of your journey with Wegovy and work towards achieving your weight loss goals. Remember to consult your healthcare provider before making significant changes.

Wegovy: Pros, Cons, and Side Effects

Wegovy (semaglutide) has gained popularity as a weight loss medication that aids individuals struggling with obesity and weight management. Developed by Novo Nordisk, this medication has shown substantial benefits for weight loss, but, like any medication, it also carries potential risks.

Let’s take a closer look at Wegovy’s “pros and cons” in terms of its benefits, side effects, and contraindications to help you understand if it’s the right choice for your weight loss journey.

What is Wegovy, and How Does it Work?

Wegovy is a prescription medication containing the active ingredient semaglutide. It belongs to the class of weight loss drugs known as GLP-1 receptor agonists. GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone involved in blood sugar control, appetite regulation, and digestion. Therefore, GLP-1 plays a significant role in weight and body mass. By mimicking GLP-1, semaglutide helps reduce appetite, increase satiety, and slow digestion, making it easier for individuals to reduce their daily caloric intake by eating less, which is crucial for weight loss.

The benefits of the “pros” of semaglutide injections do not stop at weight loss. This medication has also been shown to improve heart health and reduce the risk of heart disease and other metabolic diseases such as type 2 diabetes.

These positive effects not only improve overall health but reduce the risk of death or serious injury from sudden cardiac events such as stroke or heart attack.

Benefits of Wegovy Injections

Clinical studies have shown that Wegovy, combined with lifestyle modifications, can lead to significant weight loss. Key benefits include:

1. Substantial Weight Reduction: Studies indicate that Wegovy can help people lose around 15% of their body weight over 68 weeks, compared to 2.4% in those taking a placebo.
2. Improved Metabolic Health: Wegovy has been shown to reduce markers associated with diabetes and heart disease, such as blood sugar levels, blood pressure, and cholesterol. In fact, like many other GLP-1s, Wegovy was first approved as a diabetes medication. The cardiovascular benefits of semaglutide are so pronounced that it is now even being prescribed for patients at risk for heart disease who are not obese.
3. Enhanced Quality of Life: For many individuals, Wegovy’s weight loss benefits also improve physical function, energy levels, and psychological well-being. This is especially true when semaglutide injections are combined with a reduced calorie, balanced diet, and increased physical exercise.

Wegovy Side Effects

As with any medication, Wegovy may cause side effects ranging from mild to severe. Side effects are categorized by frequency and severity.

Common Side Effects

Most individuals experience mild to moderate side effects, especially in the initial weeks of starting Wegovy, as the body adjusts to the medication. Common side effects include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach or belly pain

These effects, particularly side effects like stomach pain, are often temporary and can subside with continued use as the body adjusts to the medication. To manage these symptoms, doctors often recommend starting at a lower dose and gradually increasing it.

Less Common Side Effects

Though less frequent, some users may experience:

• Dizziness
• Fatigue
• Upset stomach
• Bloating

These symptoms generally improve with time. However, if they persist or worsen, it’s important to consult your healthcare provider.

Rare or Severe Side Effects of Semaglutide

In rare cases, semaglutide may lead to more serious side effects, including:

• Pancreatitis: Signs of pancreatitis include severe abdominal pain, nausea, and vomiting. If you experience these symptoms, seek medical attention immediately.
• Kidney Problems: Some patients experience kidney issues, especially if dehydrated due to vomiting or diarrhea.
• Hypoglycemia: Particularly in individuals taking medications for diabetes, Wegovy can lead to low blood sugar. Symptoms include shakiness, sweating, and confusion.
• Allergic Reactions: On rare occasions, Wegovy may cause severe allergic reactions. Symptoms may include swelling of the face or throat, difficulty breathing, and a rapid heart rate.

Other Warnings and Contraindications

Certain individuals should avoid using Wegovy due to potential health risks:

• Pregnancy: Wegovy is not recommended for pregnant individuals, as weight loss medications can pose risks to fetal development.
• Personal or Family History of Thyroid Cancer: Wegovy has been associated with thyroid tumors in animal studies, and though not confirmed in humans, individuals with a personal or family history of thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN2) should avoid this medication. In addition, tell your doctor if you have a personal or family history of medullary thyroid carcinoma.
• Diabetic Retinopathy: Individuals with diabetic retinopathy may experience worsened symptoms, so caution is advised.

Never use this medication without the advice and supervision of a medical professional. Always inform your healthcare provider about your medical history to determine if Wegovy is safe.

Is it Worth It? The Pros and Cons of Wegovy

Semaglutide injections represent a breakthrough in the field of weight loss, offering a new pathway to help individuals manage obesity and reduce the risk of obesity-related medical conditions such as heart disease, high blood pressure, and type 2 diabetes. Clinical trials have shown that Wegovy, especially when paired with dietary and lifestyle modifications, can lead to substantial weight loss for many users.

For most patients, the primary appeal of Wegovy lies in its effectiveness. Studies demonstrate that people on Wegovy can lose up to 15% of their body weight—results that are often unachievable through diet and exercise alone, especially for individuals with a history of unsuccessful weight management attempts.

However, with its many benefits, semaglutide has its share of potential risks. Many users experience gastrointestinal issues, and, in rare cases, more severe side effects such as pancreatitis or kidney complications can occur. Additionally, once Wegovy is stopped, weight regain is not uncommon if lifestyle changes are not sustained. While it is hard to quote the exact price for Wegovy, the medication cost, which may not always be covered by insurance, is another factor that could be a “con” for many users.

Therefore, using Wegovy involves a careful risk/benefits analysis. Only by carefully examining the pros and cons in detail can individuals and their healthcare providers assess if Wegovy aligns with their health goals and risk tolerance.

Wegovy Pros

1. Effective for Weight Loss: Wegovy is one of the most effective medications for weight loss, especially when combined with dietary and lifestyle changes.
2. Improves Metabolic Health: It lowers blood sugar, improves insulin sensitivity, and can reduce cardiovascular risk factors.
3. Once-Weekly Dosing: Wegovy’s convenient once-weekly injection makes it easier to incorporate into a routine compared to daily medications.

Wegovy Cons

1. Potential Side Effects: While mild side effects are common, some people experience severe side effects like pancreatitis or kidney issues.
2. Cost and Insurance: Wegovy can be expensive, and insurance may not cover it for all patients.
3. Potential Weight Regain: Stopping Wegovy may result in weight regain, making long-term management necessary to maintain results.

For individuals struggling with obesity or weight-related health conditions, the benefits of Wegovy often outweigh the potential risks, especially when monitored by a healthcare provider. However, it’s essential to consider both the pros and cons, including potential side effects and costs. Contact Us today, and let us help you make an informed choice that aligns with your health goals.

You may have heard that there is an association between hair loss and taking Wegovy or similar drugs for weight management. However, in medical science, “correlation” does not necessarily mean “causation.” In other words, rather than directly caused by the medication, there could be other reasons that the few overweight people using Wegovy are also losing their hair.

Wegovy is a powerful drug for weight loss. While it is providing astonishing weight loss results for thousands of patients, like any drug, Wegovy has some potential side effects. Most of the side effects of Wegovy have to do with gastrointestinal distress, such as diarrhea, constipation, and nausea.

While it is NOT listed as one of the possible side effects of Wegovy, during the FDA-approval trials of the drug, 3% of patients experienced hair loss in the Wegovy group, as opposed to only 1% in the placebo group. Such a small number of participants reporting hair loss was not significant enough per FDA guidelines for it to be listed as one of the Wegovy side effects.

However, it did occur, if even to a small degree, and since the Wegovy clinical trials, there also have been additional anecdotal reports of hair loss among users. So, do you need to be concerned about Wegovy and hair loss? Let’s take a closer look.

Does Wegovy Really Cause Hair Loss?

While it was reported during the Wegovy clinical trials, there is actually little or no evidence that taking Wegovy directly caused hair loss in those participants or anyone else who has reported thinning hair while on the drug.

More likely, what these people are experiencing is a recognized medical condition that links rapid weight loss of any kind to hair loss, known as telogen effluvium. The condition is most likely caused by the stress and hormonal changes that occur as your body sheds a lot of pounds in a short period of time, as occurs when taking Wegovy.

It is almost always temporary, and it tends to cease once your system adjusts to your new body composition. Then, your hair starts to regrow as normal. Hair loss related to telogen effluvium usually starts about three months after your initial drop in weight, and it tends to go away on its own over a few weeks to months.

To understand this kind of weight loss-related hair loss, it is important to understand how your hair grows and sheds in the first place. Your hair normally goes through cycles of repeated growth and loss. During the growth phases, the hair follicles are stimulated by certain hormones to grow hair. During the rest phases, other hormones tell your hair to stop growing, and your old hair sheds. Then, the follicle goes back into a growth phase. Hormonal changes and other issues that can accompany hair loss on drugs like Wegovy can cause the follicles to “get stuck” in the resting phase, and this is what causes the temporary hair loss we have described as “telogen effluvium.”

Hormones and, in particular, stress hormones play a factor in telogen effluvium. Cortisol is a stress hormone; when you lose weight rapidly, it is not uncommon for your body to experience stress until it gets used to the changes brought on by dropping a lot of weight. One of the reactions to that stress could be an increase in cortisol levels. Increases in cortisol is known to cause telogen effluvium — that state when your hair follicles go into a resting phase, followed by shedding.

It is important to point out that the telogen effluvium effect is not unique to weight loss drugs like Wegovy but can and does occur almost anytime the body is put under the stress of extreme and rapid weight loss. For example, similar instances of hair loss have been reported after bariatric surgery and other medical weight loss interventions.

To sum it up, hair loss related to the use of Wegovy is quite rare. It is so uncommon indeed that it was not required to be listed as a side effect in the drug’s prescribing information or insert.

Does Mounjaro Cause Hair Loss?

Muounjaro is a similar drug to Wegovy, but it contains a different active ingredient. On November 8, 2023, it has just been approved by the FDA for weight loss. However, Mounjaro has been on the market as a type 2 diabetes drug since — Like Wegovy, hair loss is also not listed as an adverse effect in the package insert for Mounjaro. However, also like Wegovy, a clinical study from 2022 reported that hair loss occurred in 4.9% to 5.7% of people using a 5 mg to 15 mg dose of Mounjaro, compared to 0.9% of those using the placebo.

Doctors and researchers conclude that any hair loss associated with Mounjaro is due to the same impacts of telogen effluvium described above with Wegovy.

Does Ozempic Cause Hair Loss?

Ozempic shares the same active ingredient with Wegovy – semaglutide. Interestingly enough, unlike Wegovy, hair loss or alopecia was not reported as a side effect in the Ozempic approval studies, which is a pretty clear indication that semaglutide does not directly cause hair loss, but it is the associated hormonal and other bodily changes mentioned earlier.

Hair loss, therefore, is also not listed as a potential side effect in Ozempic’s insert; however, as with Wegovy and Mounjaro, it has been reported by some people using the medicine. But once again, this is a quite rare occurrence and most likely unrelated to the drug itself.

How to Prevent Hair Loss

So, what is the bottom line? Is it possible that you may temporarily lose some hair while on Wegovy? Yes, it is possible. But telogen effluvium, caused by weight loss, is uncommon, temporary and reversible. In addition, if you are really concerned about it, there are ways you can keep your hair healthy and lower the risk of hair loss while taking drugs like Wegovy, Ozempic, or Mounjaro.

Because you eat less when you are taking Wegovy or related drugs, it is possible that your hair is not getting the proper nutrients it needs to stay healthy and strong. Making sure to eat healthy and nutritious meals while you are eating less and/or taking a daily multivitamin-multimineral may help prevent telogen effluvium.

In addition to eating right or taking supplements, while on Wegovy, be gentle to your hair, avoid shampooing with harsh chemicals, and avoid dying your hair. Try not to style your hair too often or try a radical new hairstyle during your first few months on Wegovy because this can stress your hair. Speaking of stress, try to moderate your cortisol levels by taking measures to reduce stress, such as deep breathing, yoga meditation, or tai chi.

If you do experience hair loss while on Wegovy, speak to your doctor. He or she can rule out any other cause for your hair loss and also recommend ways to help minimize or reverse the condition so you can achieve your weight loss goals without pulling your hair out!

Wegovy not working at all is an uncommon occurrence; we have rarely seen total Wegovy failure at any of our weight loss clinics, and when we do, there is almost always a reason it can be solved. Basically, the reasons why Wegovy won’t work fall into one of two categories: there is something about the patient’s body that is preventing the drug from working as it normally would, or the patient is failing to use the drug correctly or is not combining it with the right kind of diet and lifestyle changes for Wegovy to be effective.

In the first case, there is little that can be done other than perhaps reworking your dose to overcome the issues that could be making you Wegovy resistant. But more often than not, if Wegovy isn’t working, it’s because of something you are not doing right that can be corrected.

How Long Does it Usually Take for Wegovy to Work?

Before you jump to the conclusion that your Wegovy injections “aren’t working,” please understand that it takes time for Wegovy to start working. Wegovy has been found to be quite effective in helping people lose significant amounts of weight.

In clinical trials, participants lost an average of 15% -16% of their body weight by week 68 on the maximum 2.4 mg once-a-week dose of Wegovy. Generally speaking, our patients tend to start seeing results much sooner than that; however, do keep in mind that in many patients, it can take several weeks or months until they start to see substantial weight loss on Wegovy.

The aforementioned trials concluded that patients could lose weight on Wegovy up to and through the 68th week of using the drug, but we have seen our patients continue to lose weight beyond that mark. Continued weight loss on Wegovy past week 68 is especially possible when combined with the kind of exercise, diet, and lifestyle counseling we give all of our Wegovy patients.

One study found that among obese adults who were simultaneously encouraged to eat appropriately and be physically active, two years of Wegovy treatment led to an average of 15% weight loss vs. only about 2-3% in the placebo group.

Five Reasons Why You May Not Be Losing Weight on Wegovy

The reasons why a person may not be losing weight on Wegovy can vary. Several things factor into your ability to lose weight with or without a weight loss drug like Wegovy. Your unique genetics, age, the amount you eat, and how much exercise you get all play a role in how well Wegov does or does not work for you.

Here are the five most common reasons why we see patients who fail to lose the amount of weight they want to on Wegovy.

Side Effects

The most common reason we see patients failing on Wegovy is because they stop taking it due to unwanted side effects. However, severe side effects on Wegovy are rare, and most of the common ones can be dealt with.

Like waiting for it to work, the best thing you can do about Wegovy side effects is to be patient. The most common side effects of Wegovy, such as nausea, diarrhea, and other gastrointestinal distress, usually fade out in time. If they do not, there are ways we can help you to mitigate them.

It is quite unusual in our practice to have to take a patient off of Wegovy due to side effects. The key is to discuss any side effects with us, and we can work to solve them.

Dosage Issues

Maybe the reason Wegovy is not working for you is you are not taking a high enough dose – yet. Wegovy is purposely “titrated,” meaning you are started out at the least effective dose, 0.25 mg injected once weekly for the first month so that your body is given a chance to get used to the medication.

Then, over the next several weeks, we slowly build up to the maximum dose of 2.4 mg after about the 17th week. So, if it seems like Wegovy is not working, especially early on, it may not kick in till you reach your maximum dose.

You May Be a Non-Responder

There are some people who simply do not respond to Wegovy. No drug is 100% effective. That does not prevent them from being FDA-approved. Every drug class has to work for a certain amount of people per set guidelines to be certified as “effective” in treating the given condition for which it is prescribed. For weight loss drugs like Wegovy, the guideline is if a patient loses more than 5% of their body weight within 3 months.

If it turns out you are a non-responder as close to 13% in the Wegovy clinical trials were, you may need to try another weight loss medication or a custom compounded version of semeglutide.

Medical Conditions

There are several medical conditions that can affect how well Wegovy works for you. For example, people with type 2 diabetes do not respond as well to Wegovy as those who are non-diabetic. A 2022 study published in JAMA found that people with diabetes only lost about 7% of their body weight after 6 months on Wegovy, as opposed to those without diabetes who lost nearly 12% of their body weight in the same time period.

Sometimes, it’s not the condition itself but the medications used to treat them that can negatively impact Wegovy’s effectiveness. Drugs to treat hypertension and some emotional disorders, for example, have been found to slow down weight loss on Wegovy.

If you have any of these conditions, it does not mean that you cannot and should not take Wegovy to lose weight, but you must keep in mind that it may not work as well for you as it might for someone who does not suffer from such ailments.

Not Adhering to Diet and Lifestyle Changes

Another quite common reason for Wegovy not working the way you expect is that you are failing to follow our advice on diet, exercise, and other lifestyle changes. We have seen too many patients who think Wegovy is some kind of magic drug that means once you are on it, you can just eat whatever you want, whenever you want.

They also make the mistake of thinking they do not have to worry about working out either. We are afraid to tell you that Wegovy simply does not work that way.

Maybe you could lose a few pounds on Wegovy if you take it weekly and do absolutely nothing else. But if you want to maximize your weight loss results, you must also make adjustments to your diet and physical activity.

One of the largest trials studying Wegovy found that the drug was most effective in participants who dropped their caloric intake by at least 500 calories daily and increased their physical activity to 150 minutes of moderate-intensity exercise (like walking) per week.

Can Wegovy stop working?

As we said earlier, in the clinical trials of Wegovy, patients continued to lose weight for up to 68 weeks, and there were those who continued to do so for two years and beyond. Wegovy has been designed for long-term use. As long as you are continuing to lose weight and not being troubled by side effects, there is little research to suggest that you will reach a point where Wegovy will stop working or that you must stop taking it.

In fact, the opposite is true; if you have been effectively losing weight on Wegovy and you do choose to stop, there is a good chance that the weight you lost will come back. So, as long as Wegovy is working for you, there is no reason to stop Wegovy.

If the idea of being on a weight loss drug potentially for the rest of life seems daunting, just think of the alternatives and all of the health issues that being obese can bring. If your doctor told you that you need to take any other kind of medication indefinitely, but it would keep you alive, you would not say “no.” You need to look at Wegovy the same way.